Feasibility study and practice of circulating air scheme in low-risk areas of high-level biosafety laboratories

Chen Xin[1][2] Wang Rong[3][4] Li Xiaobin[1][5] Liu Junjie[3] Lu Yuming[6]Guo Jianhong[1][5] Ding Aijun[7] Yang Jiuxiang[8] Tao Gang[8]

2025.02.18

The high-level biosafety laboratory is a key facility for studying and controlling highly pathogenic microorganisms. Its ventilation and air conditioning system usually uses a all-outdoor air system to effectively avoid cross-contamination. However, although the operation mode of this all-outdoor air system is guaranteed in safety, it will also cause the problem of high energy consumption, which is not in line with the policy requirements of China’s current active promotion of energy conservation and carbon reduction in the construction field. In order to solve this problem, this paper draws on the relevant standards and requirements at home and abroad, and combines the specific conditions of the operation of a high-level biosafety laboratory. The feasibility study analysis and practical exploration of the low-risk area of the high-level biosafety laboratory from the outdoor air system to the circulating air system are carried out. The purpose is to provide references for how to use the circulating air system to achieve energy-saving operation in some ventilation and air conditioning systems of high-level biosafety laboratories.